The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.
نویسندگان
چکیده
منابع مشابه
Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex
Transgenic mice carrying and expressing the human CD3 epsilon gene incorporate the corresponding protein product into T cell receptor (TCR)/CD3 complexes on thymocyte and T cell surfaces. The chimeric antigen receptors allow normal T cell development and selection of repertoires in vivo and are able to transduce activation signals in vitro. We have exploited the ability to distinguish mouse (m)...
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Analyses of TCR-bearing murine and human T cells have defined a unique subpopulation of T cells that express the TCR-gamma/delta proteins. The specificity of TCR-gamma/delta T cells and their role in the immune response have not yet been elucidated. Here we examine alloreactive TCR-gamma/delta T cell lines and clones that recognize MHC-encoded antigens. A BALB/c nu/nu (H-2d)-derived H-2k specif...
متن کاملThe T cell antigen receptor beta chain interacts with the extracellular domain of CD3-gamma.
Selective pairwise interactions between a number of CD3 chains and the clonotypic T cell antigen receptor (TCR-alpha, -beta) chains have recently been reported. What still remains unanswered is the site of interaction between TCR-beta and CD3-gamma chains. To examine the region of interaction between TCR-beta and CD3-gamma chains, a variety of genetically altered TCR-beta and CD3-gamma chains w...
متن کاملRole of CD3 gamma in T cell receptor assembly
The T cell receptor (TCR) consists of the Ti alpha beta heterodimer and the associated CD3 gamma delta epsilon and zeta 2 chains. The structural relationships between the subunits of the TCR complex are still not fully known. In this study we examined the role of the extracellular (EC), transmembrane (TM), and cytoplasmic (CY) domain of CD3 gamma in assembly and cell surface expression of the c...
متن کاملThe gamma and epsilon subunits of the CD3 complex inhibit pre-Golgi degradation of newly synthesized T cell antigen receptors
The T cell receptor for antigen (TCR) is composed of six different transmembrane proteins. T cells carefully control the intracellular transport of the receptor and allow only complete receptors to reach the plasma membrane. In an attempt to understand how T cells regulate this process, we used c-DNA transfection and subunit-specific antibodies to follow the intracellular transport of five subu...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1991
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1991.tb08023.x